PHYTO-C

SKIN CARE

全球知名維生素C穩定性專利技術護膚品牌

歐瑪博士

Dr. Mostafa Omar

生藥學專家及植物化學科學家
羅德島大學藥學系教授
杜克大學皮膚醫學中心研究者

國際生化學教授與植物化學科學家 Dr. Mostafa Omar 頂尖專利技術,將維他命C調配成高度活性又穩定的配方使維他命C可以直接經由局部塗抹方式達到肌膚超飽和吸收。
Dr. Omar 數十年來致力於維生素與抗老研究,獲得美國國家癌症研究中心 NCI(National Cancer Institute)及與美國國立衛生研究院 NIH(National Institute of Health)授予研發經費支持。

Dr. Mostafa Omar 榮獲 University of Rhode Island 羅德島大學頒發三項最高成就獎。取得美國國家癌症研究中心(NCI)委託研究維他命C如何有效治療及預防皮膚癌,並獲得國家衛生研究院(NIH)及美國國家衛生基金會(NSF)頒發四項獎學金,奠定了其「左旋C之父」的地位。

 

National Cancer Institute

 
NCI Grant#1 R43-CA83538-01A1:通過防止抗氧化劑在皮膚中的 UV 光損傷;
NCI Grant#1 R43-CA94484-01:通過局部硒對皮膚的光保護,
其發表於各醫學研究專業期刊,研究中獲得兩項重要的專利:
橄欖葉提取物:專利#6,743,449;B2 / Aleoferon:專利#4,861,761,
研究維他命C如何有效治療及預防皮膚癌。
並獲得國家衛生研究院(NIH)及美國國家衛生基金會(NSF)頒發四項獎學金。

品牌故事

1983 年

Dr. Omar 於紐澤西建立 PHYTO-C 實驗室,專司草本植物與天然維他命C研究,並在羅德島大學及杜克大學醫學研究中心從事研究工作,自此 Dr. Omar 享有了左旋C(維他命C)之父的尊稱。

1993 年

Dr.Omar 將維他命C配方提供給當時新成立的醫療護膚品牌 Cellex-C,此為 Dr.Omar 調配之創始維他命C配方,隨即塗抹式 L-維他命C引發了皮膚抗老化及醫學美容界革命性的狂瀾!

1997 年

Dr.Omar 協助創辦了總部位於美國德州的 SkinCeutical 公司,擔任該公司專屬配方提供者及顧問,歐瑪博士所調配的第二代 L-維他命C配方,再度引領醫學美容市場的潮流!

2003 年

全球化妝品龍頭萊雅 (LOREAL) 購併美國 SkinCeuticals (中文名稱:杜克),Dr. Omar 因經營理念不同而終止與 SkinCeuticals 公司的合作關係,並停止授權維他命C專屬配方給予該公司。

2005 年

Dr.Omar 以中文「歐瑪左旋C」為品牌,由創新生技銷售出全球第一瓶 PHYTO-C 產品,「PHYTO-C」成為專業品牌標竿,營銷全球,並由專業醫師推薦使用,受到專業醫師推崇。

2008 年

Dr. Omar 提供了部分商品給「杜克C」(C-SKIN)於台灣銷售。

2012 年

Dr.Omar 發表最新抗氧化配方「Superheal™ O-Live」 愛美人士可同步感受國際美容新科技!

2018 All New Products

時至今日,PhytoCeuticals 仍以實效口碑著稱,憑藉歐瑪博士 PHYTO-C 維他命C專利配方風靡全球將近 30 年而歷久不衰,也再次證明了 PHYTO-C 歐瑪維他命C「專利配方」的獨特之處!

Dr. Omar 投入十年來最新研究成果,升級調製配方,全球同步發表多項新商品及新抗老成份,讓您感受新一代產品卓越抗老成效!

時至今日,PhytoCeuticals 仍以實效口碑著稱,憑藉歐瑪博士 PHYTO-C 維他命C專利配方風靡全球將近 30 年而歷久不衰,也再次證明了 PHYTO-C 歐瑪維他命C「專利配方」的獨特之處!

Dr. Omar 投入十年來最新研究成果,升級調製配方,全球同步發表多項新商品及新抗老成份,讓您感受新一代產品卓越抗老成效!

學術研究

把維他命C說清楚

 

人體無法自行合成維他命C(L-抗壞血酸),必需由從食物來源獲得維他命C,
然而從飲食吸收後分佈到皮膚的維他命C大約只有 7% ,維他命C對皮膚的好處,眾所皆知,但是如果你希望讓皮膚吸收多一點維他命C,除了從水果中多攝取外,另一個方法就是直接用外塗的方法使用維他命C。

 

Dr. MostaFa Omar 於杜克大學研究資料顯示:
維他命C是一種水溶性維他命,對於皮膚來說,有促進膠原蛋白增生,加速傷口癒合,增強微血管結構完整性,抑制與淡化黑色素,減低紫外線造成皮膚曬紅情形以及抗發炎與抗氧化等多種功能,此外維他命C在體內許多的代謝過程中是當作輔助因子(輔助因子)的角色,所以維他命C可謂是相當多功能的抗老成份。

 

您塗抹的維他命C有效嗎?
但因為維他命C容易氧化不穩定,無法長時間保存在保養品中,所以廠商就研發出各種不同的劑型及衍生物,讓維他命C能更穩定的長效保存。
但這些衍生物還是必須先進入皮膚,經轉化成活性維他命C (L- Ascorbic Acid) 後才會發揮作用。所以不同的維他命C劑型或衍生物就會有不同的經皮吸收度及轉換率及效果的差異性。於是不要以為擦了維他命C就一定有效果,一定還要看看劑型與配方,相關成份種類,濃度及包裝設計才能了解。

 

維他命C還原碘酒測試的迷失
在市面上廣告常常會以還原碘酒(由棕色變透明)的作用來測試產品是否具有維他命C的活性。這只是一種商業手法,只能說維他命C產品可還原碘酒的能力,並無法表示其美白效用或抗氧化的活性,更不能引申說,肌膚內的黑色素也會如此變化而還原變透明。這不僅是錯誤的訊息,還誤導消費者,來誇大宣傳效果。

 

左旋C還是右旋C?
在化學的命名上維他命C應該是 L -(+)- 抗壞血酸。這裡的 L 指的是分子結構上的左型(式)(L型)和右型(式)(D型)。在分子的立體結構上維他命C有不對稱碳原子。所謂不對稱碳原子是指這個碳原子所接臨的 4 個原子或基團完全不同。這樣的話在結構上就會有光學異構物(stereoisomers)產生,簡單說就是會兩個分子其組成是一模一樣,但彼此立體結構卻呈現鏡像的狀況。這在化學結構上要區分這兩種分子就以 L 型及 D 型來區分。

而分子特性中還有一種稱為旋光性(optical activity),也就是把具有光學活性的化合物放在測試管中,利用平面偏光通過測試管,眼睛面向入射的偏光方向,如果偏光最後向右旋轉(順時鐘)這一化合物就是「右旋性」化合物(以 (+),D 或 dextrorotatory 表示)。如果偏光最後向左旋轉(逆時鐘)這一化合物就稱為「左旋性」化合物可以以(-), L 或 levorotatory 表示)。維他命C在室溫(25℃)鈉燈光源(波長 589 nm)下檢測,其水溶液的旋亮度約為 +21 度,因此維他命C的確是「右旋性」的化合物。

L – D(d; +)/(l; -)這兩種表示法是完全獨立的,也就是說並不是 L 型的化學物其旋光性一定要左旋性(-),維他命C就是個最好的例子我們人體及皮膚可以利用的維他命C,在化學結構及特性上剛好就是左型(式)- 右旋維他命C所以原先大家所熟知的維他命C其實是把左型(式)誤翻成左旋的結果。

 

目前常見的維他命C劑型種類,比較如下:
1. 水解專利型純維他命C
2. 維他命C相關衍生物(酯化型維他命C及維生素C葡萄糖苷)
3. 純維他命C(安瓶粉末)

 

結論:
整體效果而言、各劑型皆有優缺點
(一) 純維他命C(歐瑪專利型):整體效果最令人滿意,如不考慮價格因素,可列為優先選擇。
(二) 維他命C:最大功能是抗氧化及中和自由基,請妥善利用及選擇高活性劑型才是王道。
(三) 以維他命C相關衍生物及酯化型:穩定度高,但活性低,效果抗氧化有限,是典型安慰劑。
(四) 純維他命C(粉末):混和後 10 天內用完即可增加保存高活性,考慮性價比是不錯的選擇。

 


 

維他命C(歐瑪左旋C)的知識

 

維他命C(歐瑪左旋C)的優點

人體主要有效的抗氧化劑 (A major antioxidant in body)
中和自由基 (Neutralized free-radicals)
促進膠原生成和彈力蛋白增生 (Stimulates collagen growth)
抑制黑色素形成,減少褐斑 (Restrains melanin formation)
提供光保護作用,預防免疫力受抑制現象 (Prevents UV Immunosuppression)
抗菌抗發炎功效促進傷口癒合 (An Anti-inflammatory and promotes healing)
提升皮膚保濕作用 (Retains water to the skin)

 

有效的維他命C應具備以下要素:

應呈左旋抗壞血酸形式
細胞最佳吸收之濃度為 7% ~ 20% 之間
經局部塗抹可提供細胞高吸收率之配方
可直接被皮膚細胞轉換辨識利用
可儲存於細胞 (最高可達 72 小時)
不會被洗去或擦去 (不同於一般保養品)

 


 

關鍵配方與價值

 

Importance of L-Ascorbic Acid (Vitamin C)

At Phyto-C Skin Care, vitamin C is not merely a step in one’s skin care regimen. It is an integral part of a skincare regimen. Why? Vitamin C is well known for it’s antioxidant properties and is a key ingredient that increases the potency and efficacy of other key ingredients. Dr. Mostafa Omar, President and founder of Phtyo-C Skin Care and inventor of topical Vitamin C, develops each and every formula with safety, efficacy, and purity to relieve the appearance of major skin concerns.

Vitamin C has been clinically proven to reduce the appearance of fine lines and wrinkles and assist with improving the appearance of skin elasticity through a series of biological and physiological processes. Phyto-C is the only skin care company to maintain its proprietary technology on vitamin C stability without the use of parabens, ferulic acid, or vitamin C derivatives.

 

Importance of Formulation for Optimal Skin Permutation

Cosmetic substances navigate through the skin primarily through the pores of the hair follicles, the sweat glands, or through the protein/lipid domains of the stratum corneum. The importance of this is for maximum efficacy of the formulation. In the initial transient diffusion stage, penetration occurs through the hair follicles and the ducts. Water-soluble molecules with low lipid solubility will usually pass through the pores, whereas lip-soluble materials pass through protein/lipid domains of the stratum corneum.

L-Ascorbic acid (LAA), is the foundation of which Phyto-C Skin care was built on. Phyto-C’s high-concentration antioxidants are designed for optimized absorption on skin and proven in published, peer-reviewed scientific journals, and supported by a grant from the National Cancer Institute. Our vitamin C serums reduce the appearance of fine lines, wrinkles, and discoloration. In collaboration with Duke University, Dr. Omar was able to optimize his vitamin C formulations for unprecedented skin absorption. These parameters are as follows:

.The highest concentration of L-Ascorbic Acid clinically proven to penetrate the skin is 20%. Any product claiming to contain more than 20% L-Ascorbic Acid will not penetrate the skin and will see no results or minimal results.

.Vitamin C has been clinically proven to reduce the appearance of fine lines and wrinkles and assist with improving the appearance of skin elasticity through a series of biological and physiological processes. Phyto-C is the only skin care company to maintain its proprietary technology on vitamin C stability without the use of parabens, ferulic acid, or vitamin C derivatives.

.A pH of 3.5 or lower is essential for L-Ascorbic absorption. After only three days of applying topical L-Ascorbic Acid to the skin, tissue levels will be saturated and levels have been found to be approximately 20 times the normal tissue level. L-Ascorbic Acid remains in the skin for approximately four days after topical application.

.L-Ascorbic Acid is the only form of Vitamin C clinically tested to penetrate the skin.

 

【閱讀文獻資料】

 


歷年研究成果

 

“Prevention of UV Photoinjury in Skin by Antioxidants”, personal communication, MM Omar, to be published re NIH, NCI grant #1 R43, CA83538-01A1, (2004)

“UV Photoprotection by Combination Topical Antioxidants vitamin C and E”, JY Lin, MA Selim, CR Shea, JM Grichnik, MM Omar, NA Monterio Riviere, SR Pinnell; Journal of the American Academy of Dermatology 48:866-74, (2003)

“Topical L-Ascorbic Acid: Percutaneous Absorption Studies”, SR Pinnell, H Yang, MM Omar, N Monterio, HV DeBuys, LC Walker, Y Wang, M Levins, Dermatology Surgery 27:137-142, (2001)

“Photoprotection of Skin by Topical Selenium”, Mostafa M. Omar, Ph.D., NCI Grant #1-R43-CA94484-01, (March 2001)

“A Topical Formulation Containing L-Tyrosine Does Not Intensify Pigmentation In Human Skin”, Ho, Julia, Omar, M., Riviere,J. and Pinnell, S.R., J Appl Cosmetol.17, 82-85, (July/September 1999)

“Phenolic Compounds in Botanical Extracts Used in Foods, Flavors, Cosmetics & Pharmaceuticals”, M. Omar, Am. Chem. Soc. Symposium Book Series, 506, 154-168, (1991)

“Aloeferon, Discovery, Chemistry & Exploratory Study of the Pharmacological Effects”; M. Omar & V. Madis, U.S. Patent # 4861761, (1989)

“Solubility of Paracetamol by Various Hydrotropic Agents”, Y. Hamza, A. Paruta & M. Omar, Drug Development & Industrial Pharmacy,11(8), 1577-1596, (1985)

“Certain Poisonous Plants of Egypt, A Scientific Manual”, S. Hilal, H.W. Youngken & M. Omar, National Information & Documentation Center, Cairo, Egypt, (1984)

“Certain Poisonous Plants of Egypt, A Manual for Egyptians & Visitors, Al-Ahram Press, Cairo, Egypt, (1984)

“Aloeferon, Effects on Human Foreskin Fibroblast Cells”, M. Omar, V.H. Madis, Am. Soc. Pharm(ASP), Texas, (1984)

“Chemistry & Toxicity of Trichodesma Africanum, Family Boraganaceae”, H.W. Youngken and M. Omar, J Natural Products (LLOYDIA), 46(2), 153-156, (1983)

“Pharmacognostical Study of Gossypium Barbadense, Family Malvaceae”, M. Omar, G.H. Mahran & M. Salah, J African Medicinal Plants,30, 1, (1978)

 

 


橄欖葉萃取物研究成果

 

 

shows enhanced levels of antioxidant protection provided when combining Olive Leaf extract, Vitamin A, Vitamin C, and Vitamin E compared to those of the vitamins and extracts in different combinations.

The ancient Egyptians were the first to use Olive Leaf Extract.

Olive Leaf Extract (OLE) is derived from the olive tree (Olea Europaea) and contains Oleuropein which has powerful antioxidant properties to assist in improving the look of fine lines, wrinkles, irritated an dry skin.

Olive leaf extract has been clinically tested to have a higher antioxidant protection factor when used in conjunction with vitamins A, C, and E than those same ingredients without inclusion of OLE.

 


 

各項研究資料

 

The Physiology of Vitamin C
Vitamin C (L-Ascorbic Acid) is not synthesized by the body. It must be provided in the diet. Body stores are limited by control mechanism which allow a maximum of 1200 mg to be absorbed daily. The half life of Vitamin C is 10-20 days, so that after three weeks Vitamin C is mostly depleted in the absence of further ingestion. The minimum daily requirement for Vitamin C is 200 mg. (Levine et al., Proc Natl Acad Sci, 1996). Vitamin C is a major antioxidant in the body. In addition, it is important in collagen synthesis. The only form of Vitamin C that the body can recognize and use is L-Ascorbis Acid, In order to work, Vitamin C must first penetrate the skin and be present there in the active form, L0Ascorbic Acid. Typically, the skin a good barrier, protecting outside substances from entering skin, and Vitamin C is inherently unstable at neutral pH.

Vitamin C is an Antioxidant
Antioxidants protect skin by neutralizing reactive oxygen species, the oxidative “bomba” generated when skin is exposed to sunlight – bomba which otherwise would destroy skin and its components (Shindo et al., J Invest Derm, 1994). Antioxidants work by naturalizing a series of oxygen molecular species known as oxygen species are stimulated by ultraviolet light and also occur naturally during normal metabolism in the oxygen atmosphere in which we live. L-Ascorbic Acid neutralizes reactive oxygen species including superoxide anion singlet oxygen and hydroxyl radical (Halliwell and Gutteridge Arch of Biochem & Biophye, 1990).

Ultraviolet Radiation Destroys L-Ascorbic Acid in Skin
When skin is exposed to ultraviolet light measurements show that two0thirds of L-Ascorbic Acid in skin is destroyed. Scientists believe that L-Ascorbic Acid’s role as an antioxidant is essential in protecting skin from oxidative damage produced by ultraviolet light exposure and the associated inflammatory reaction. It is believed that this oxidative insult (generation of oxidative free radicals) results in damage to other skin constituents including collagen, elastic, proteoglycan, as well as cell membranes and nuclear constituents. In time, it is believed that these changes may result in connective tissue breakdown (aging and wrinkles) and skin cancer.

Ultraviolet Radiation and the Ultraviolet Spectrum
Exposure to ultraviolet radiation (UVR) is a well- documented health hazard. If it were not for a multi-layered defensive system, humans would die in the oxygen-rich environment in which they live., the ultraviolet spectrum is divided into the following key regions: UVC (270 – 290 nm), UVB ( 290-320 nm), UVAII (320 – 340 nm), and UVAI (340 – 400 nm).

The ozone layer protects humans from damage against UVC rays
The number 2 and 3 carbons are double-bonded and contain an acid-ignitable hydrogen in the water (pk=4.2). L-Ascorbic Acid also is a moderately strong reducing agent. These properties, which lead to instability in the L-Ascorbic Acid structure are well known and have been burdensome to pharmacologists when attempting to formulate active, stable L-Ascorbic Acid solution. At neutral or higher pH, which is the typical cosmetic formulation, L-Ascorbic Acid becomes the notoriously unstable assorbate anion. For these reasons among others scientists have had difficulty formulating stable solutions of L-Ascorbic Acid which would be beneficial for cosmetic, dermatologic or ophthalmic needs. Nevertheless, because of the many beneficial effects attributed to L-Ascorbic Acid, Numerous attempts have been made to overcome these difficulties. Excessive Sun Exposure is the Most Preventable Causes of Melanoma Formulation. The most important preventable cause of melanoma is excessive sun exposure to UV radiation. Malignant melanoma also has been linked to past sunburns and sun exposure at younger ages. Other possible causes of melanoma include genetic factors and immune system deficiencies.

Topical Vitamin C Prevents UV Immunosuppresion
Undoubtedly the most exciting research to emerge from research studies is that topical Vitamin C prevents UV immunosuppression. (Nakamura T., et al ., J Invest Dermatoll, 1997). This phenomenon, in which the activity of the immune system is stifled following exposures to sunlight, occurs in approximately one-third of humans, but in over 90 percent of individuals who get skin cancer, both melanoma and non melanoma skin cancers (Granstein R Arch Dematol. 1995; Streilein, W., in Gilchrest, B., Photoprotection, 1995).

Topical Vitamin C Controls Inflammation and Promoted Healing
Topical Vitamin C is capable of controlling the inflammatory response associated with ultraviolet light (sunburn). Topical Vitamin C is protective even when it is applied after sun exposure (Darret al ., 1992). It is also helpful in speeding the healing process. It is often recommended as a pre-and post operative regimen for laser resurfacing patients. Dermatologic surgeons recommend using it as long as possible prior to laser resurfacing and beginning again as early as fourteen days following surgery (Alster and West, 1997).